HuagongsheHuagongshe Chemistry Print Report · For research reference only
Leflunomide → 4-(Trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Leflunomide | HCID 3899 | — |
| Reactant | 5-Methylisoxazole-4-carboxylic acid | HCID 1425240 | — |
| Product | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Product | 5-Methylisoxazole-4-carboxylic acid | HCID 1425240 | — |
Reaction Steps
A process for synthesizing leflunomide from 5-methylisoxazole-4-carboxylic acid and 4-trifluoromethylaniline is provided in which the carboxylic acid group of 5-methylisoxazole-4-carboxylic acid is chlorinated, forming 5-methylisoxazole-4-carboxylic acid chloride. The acid chloride is then reacted without intermediate distillation with 4-trifluoromethylaniline in the presence of an alkali metal or alkaline-earth metal bicarbonate acid scavenger.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723855B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-6934a2ba5240440b84303e5c9cde0c8c |
| Source note | uspto-grants-2004_04 |