HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2086372Generated: October 30, 2026
Thionyl Chloride → 5-Methyl-1,2-oxazole-4-carbonyl chloride
https://huagongshe.com/reaction/2086372
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Methylisoxazole-4-carboxylic acid | HCID 1425240 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Methyl-1,2-oxazole-4-carbonyl chloride | HCID 2759917 | 99% |
Reaction Steps
A mixture of 5-methylisoxazole-4-carboxylic acid (5 g, 39.4 mm), SOCl2 (15 ml, 205.8 mm) and toluene (15 ml) was heated to 79±1° C. and stirred for about 4-5 h. Excess SOCl2 and toluene were evaporated under vacuum (50 torr) at 70° C. to give the title compound (≧99% purity) as a pale yellow liquid residue identical to that of Example 1(a).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06723855B2 |
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| Source dataset | uspto-grants-2004_04 |
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| ORD ID | ord-3ddabe338b9f47bf8baa0e5c10c5d703 |
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| Source note | uspto-grants-2004_04 |
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