HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 10271219, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 22727330 | HCID 22727330 | — |
| Product | HCID 10271219 | HCID 10271219 | 70% |
Reaction Steps
About 2 min after dissolving 3-[3-(2-chlorophenyl)isoxazol-5-yl]propanal (15.8 mg, 0.09 mmol) and 1-phenylpiperazine (13.4, 0.07 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (42.6 mg, 0.2 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 36 hr and followed the same processes as in Example 1 to obtain 17.9 mg (70.0%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723724B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-ea0b6afb3a9e40c9aa03af936956af5c |
| Source note | uspto-grants-2004_04 |