HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzhydrylpiperazine → HCID 22727345, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzhydrylpiperazine | HCID 70048 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 22727338 | HCID 22727338 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22727345 | HCID 22727345 | 95.3% |
Reaction Steps
About 2 min after dissolving 3-[3-(4-chlorophenyl)isoxazol-5-yl]propanal (10 mg, 0.05 mmol) and 1-(diphenylmethyl)piperazine (11 mg, 0.04 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (27 mg, 0.13 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 2.75 hr and followed the same processes as in Example 1 to obtain 18 mg (90.8%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723724B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-87b04dd1fce8446caee119ff24f7127a |
| Source note | uspto-grants-2004_04 |