HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 10115728, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1-((2-(Trifluoromethyl)phenyl)methyl)piperazine | HCID 3023322 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 14816484 | HCID 14816484 | — |
| Product | HCID 10115728 | HCID 10115728 | 94.4% |
Reaction Steps
About 2 min after dissolving 3-(3-phenylisoxazol-5-yl)propanal (10 mg, 0.05 mmol) and 1-[2-(trifluoromethyl)benyl]piperazine (10.4, 0.04 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (26.7 mg, 0.13 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 18.5 hr and followed the same processes as in Example 1 to obtain 18.4 mg (94.4%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723724B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-d5debcf492c34fa4b646e1189a00334b |
| Source note | uspto-grants-2004_04 |