HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((2-(Trifluoromethyl)phenyl)methyl)piperazine → HCID 10181427, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((2-(Trifluoromethyl)phenyl)methyl)piperazine | HCID 3023322 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 22727325 | HCID 22727325 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10181427 | HCID 10181427 | 62.7% |
Reaction Steps
About 2 min after dissolving 3-(3-(2-thienyl)isoxazol-5-yl)propanal (10 mg, 0.05 mmol) and 1-[2-(trifluoromethyl)benyl]piperazine (10.0, 0.05 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (31 mg, 0.14 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 17 hr and followed the same processes as in Example 1 to obtain 13.1 mg (62.7%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723724B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-e69065147f284ddbb93d1e7fe1b1a5e0 |
| Source note | uspto-grants-2004_04 |