HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((2-(Trifluoromethyl)phenyl)methyl)piperazine → HCID 10229830, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((2-(Trifluoromethyl)phenyl)methyl)piperazine | HCID 3023322 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 22727349 | HCID 22727349 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10229830 | HCID 10229830 | 93.9% |
Reaction Steps
About 2 min after dissolving 3-[3-(3-phenoxyphenyl)isoxazol-5-yl]propanal (10 mg, 0.03 mmol) and 1-[2-(trifluoromethyl)benzyl]piperazine (7.1, 0.03 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (22 mg, 0.10 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 4 hr and followed the same processes as in Example 1 to obtain 14.7 mg (82.7%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723724B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-f235beba1ba74ecc9356adbd85d19619 |
| Source note | uspto-grants-2004_04 |