HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzylpiperazine → HCID 10133646, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 22727357 | HCID 22727357 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10133646 | HCID 10133646 | 58.2% |
Reaction Steps
About 2 min after dissolving 3-(3-(1,3-thiazol-2-yl)isoxazol-5-yl)propanal (10 mg, 0.05 mmol) and 1-benylpiperazine (8.3, 0.05 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (31 mg, 0.14 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 4.1 hr and followed the same processes as in Example 1 to obtain 10.3 mg (58.2%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723724B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-9d88f5a3d2ae40e492fe40d9d068f53e |
| Source note | uspto-grants-2004_04 |