HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzylpiperazine → HCID 10155514, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 14816484 | HCID 14816484 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10155514 | HCID 10155514 | 54.5% |
Reaction Steps
About 2 min after dissolving 3-(3-phenylisoxazol-5-yl)propanal (20 mg, 0.10 mmol) and 1-benylpiperazine (17.4, 0.10 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (64 mg, 0.30 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 4.1 hr and followed the same processes as in Example 1 to obtain 19.7 mg (54.5%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723724B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-166accb4d961414eb0e6ea6addb03230 |
| Source note | uspto-grants-2004_04 |