HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzylpiperazine → HCID 10275923, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 22727349 | HCID 22727349 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10275923 | HCID 10275923 | 97.6% |
Reaction Steps
About 2 min after dissolving 3-[3-(3-phenoxypheny)isoxazol-5-yl]propanal (20 mg, 0.07 mmol) and 1-benylpiperazine (11.9, 0.07 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (43 mg, 0.20 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 4.5 hr and followed the same processes as in Example 1 to obtain 30.2 mg (97.6%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723724B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-109449edb11a427aad5033df878a5743 |
| Source note | uspto-grants-2004_04 |