HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((2-(Trifluoromethyl)phenyl)methyl)piperazine → HCID 10278027, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((2-(Trifluoromethyl)phenyl)methyl)piperazine | HCID 3023322 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 22727355 | HCID 22727355 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10278027 | HCID 10278027 | 83.2% |
Reaction Steps
About 2 min after dissolving 3-[3-(2,4-dimethoxypheny)isoxazol-5-yl]propanal (10 mg, 0.04 mmol) and 1-[2-(trifluoromethyl)benzyl]piperazine (8.0, 0.04 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (24 mg, 0.12 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 23.5 hr and followed the same processes as in Example 1 to obtain 15.6 mg (83.2%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723724B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-8a89a8c72add474d90d484dec98fefb1 |
| Source note | uspto-grants-2004_04 |