Diisopropylethylamine → HCID 10277093, compound

Participants

Reaction Steps

About 2 min after dissolving 3-[3-(3-phenoxyphenyl)isoxazol-5-yl]propanal (40.8 mg, 0.14 mmol), (2-chlorophenyl)piperidine HCl (27.0 mg, 0.12 mmol), and diisopropylethyl amine (20.2, 0.12 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (73.8 mg, 0.35 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 22 hr and followed the same processes as in Example 1 to obtain 52.7 mg (95.6%) of the target compound.

Provenance & Evidence