HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 22727360, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 22727343 | HCID 22727343 | — |
| Reactant | HCID 23153645 | HCID 23153645 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22727360 | HCID 22727360 | 74.2% |
Reaction Steps
About 2 min after dissolving 3-[3-(3,4-dimethoxyphenyl)isoxazol-5-yl]propanal (22.1 mg, 0.09 mmol), (2-chlorophenyl)piperidine HCl (20.6 mg, 0.09 mmol), and diisopropylethyl amine (14.8, 0.09 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (54.0 mg, 0.26 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 20 hr and followed the same processes as in Example 1 to obtain 28.5 mg (74.2%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723724B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-c3ac2a1ffabe457aa17683db64728827 |
| Source note | uspto-grants-2004_04 |