Acetic Acid → HCID 10161526, compound

Participants

Reaction Steps

About 2 min after dissolving 3-(3-(2-thienyl)isoxazol-5-yl)butanal (14 mg, 0.063 mmol) and 1-(diphenylmethyl)piperazine (15.9 mg, 0.063 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (40.1 mg, 0.189 mmol), cold acetic acid (4.4, 0.077 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 17 hr and followed the same processes as in Example 1 to obtain 5.5 mg (19.1%) of the target compound.

Provenance & Evidence