Acetic Acid → HCID 10156694, compound

Participants

Reaction Steps

About 2 min after dissolving 3-(3-(2-thienyl)isoxazol-5-yl)butanal (21 mg, 0.095 mmol) and 1-benzylpiperazine (16.5, 0.095 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (60.4 mg, 0.285 mmol), cold acetic acid (6.5, 0.114 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 4.2 hr and followed the same processes as in Example 1 to obtain 13.9 mg (81.0%) of the target compound.

Provenance & Evidence