Acetic Acid → HCID 10226938, compound

Participants

Reaction Steps

About 2 min after dissolving 3-[3-(3-phenoxyphenyl)isoxazol-5-yl]butanal (31 mg, 0.101 mmol) and 1-benzylpiperazine (17.6, 0.101 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (64.2 mg, 0.303 mmol), cold acetic acid (6.9, 0.121 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 17 hr and followed the same processes as in Example 1 to obtain 20.1 mg (42.6%) of the target compound.

Provenance & Evidence