HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperidine → HCID 22727358, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperidine | HCID 20038 | — |
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 22727329 | HCID 22727329 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22727358 | HCID 22727358 | 94.7% |
Reaction Steps
About 2 min after dissolving 3-(3-(2-thienyl)isoxazol-5-yl)butanal (23.5 mg, 0.106 mmol) and 1-phenylpiperidine (16.2, 0.106 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (67.4 mg, 0.318 mmol), cold acetic acid (7.3, 0.127 1mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 3 hr and followed the same processes as in Example 1 to obtain 36.9 mg (94.7%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723724B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-77ec5df1d8a744ae95a834b3402de957 |
| Source note | uspto-grants-2004_04 |