Diisopropylethylamine → HCID 22727346, compound

Participants

Reaction Steps

About 2 min after dissolving 3-[3-(3,4-dimethoxyphenyl)isoxazol-5-yl]butanal (34.4 mg, 0.125 mmol), 1-(2-methylphenyl)piperidine HCl (24.2 mg, 0.114 mmol) and diisopropylethyl amine (19.9, 0.114 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (72.5 mg, 0.342 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 3 hr and followed the same processes as in Example 1 to obtain 30.5 mg (61.4%) of the target compound.

Provenance & Evidence