Water → HCID 20721891, compound

Participants

Reaction Steps

In 500 ml of N,N-dimethylacetamide (DMAc) was dissolved 100 g of thiophene-2-acetic acid, and to the resulting solution was added 31 g of sodium hydroxide, followed by stirring at room temperature for 10 minutes. Then, 112 g of 2-chloroethyl vinyl ether was added thereto and the mixture was stirred at 120° C. for 2 hours. The deposition of salt was observed. To the reaction solution were added water and ethyl acetate, and the mixture was subjected to separation procedure. The organic phase was washed three times with water, dried, concentrated and distilled under a reduced pressure to obtain the desired compound (X-1). The desired compound (X-1) was identified by NMR.

Provenance & Evidence