4'-Fluoroacetophenone → 4-Fluorophenylglyoxal hydrate

HRID 2086550Notes

Reaction equation

HRID 2086550 reaction equation
O.[C:2]1([C:8]([CH:10]=[O:11])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:12]C1C=CC(C(=O)C)=CC=1>>[OH2:9].[F:12][C:5]1[CH:6]=[CH:7][C:2]([C:8]([CH:10]=[O:11])=[O:9])=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 98284'-FluoroacetophenoneHCID 12215922Glyoxal, phenyl-, hydrate

Product 1

HCID 27374704-Fluorophenylglyoxal hydrate

Procedure

The title compound was prepared using essentially the same procedure as described by H. A. Riley and A. R. Gray in Organic Synthesis, Collective Volume II, p. 509 for the preparation of phenylglyoxal hydrate, but using 4′-fluoroacetophenone in place of acetophenone.

Sources & evidence

ORD record
ord-518d1a45cbd74b60a796d8dc569cf6db
Source dataset
uspto-grants-2004_04
Patent number
US06727244B2

Reaction notes

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