HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 8-Azaspiro(4.5)decane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | dichloromethane MeOH Et3N | HCID 21913430 | — |
| Product | 8-Azaspiro(4.5)decane | HCID 437152 | 95% |
Reaction Steps
Was prepared from (3,3-pentamethylenglutarimide by lithium aluminium hydride reduction in tetrahydrofurane under standard conditions. Flash chromatography (silica, eluent dichloromethane/methanol/triethylamine 10:2:0.1) afforded the title compound as light yellow oil (>95% yield). MS 154(M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727247B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-80938923191a4c7fbc122777e4485d2d |
| Source note | uspto-grants-2004_04 |