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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2086566Generated: November 1, 2026

Triethylamine → Trans-3-(naphth-2-yl)-acrylic acid-N-(2-carboxy-4-fluoro-phenyl)-amide

https://huagongshe.com/reaction/2086566

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylamineHCID 8471—
Reactant2-Amino-5-fluorobenzoic acidHCID 101412—
Reactant(E)-3-(2-naphthyl)propenoyl chlorideHCID 11830880—
SolventTetrahydrofuranHCID 8028—
ProductTrans-3-(naphth-2-yl)-acrylic acid-N-(2-carboxy-4-fluoro-phenyl)-amideHCID 22724890—

Reaction Steps

Prepared analogously to Example 31 from trans-3-(naphth-2-yl)-acrylic acid chloride and 2-amino-5-fluoro-benzoic acid in tetrahydrofuran with the addition of triethylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06727250B2
Source datasetuspto-grants-2004_04
ORD IDord-a7ffaa6976574e37bfeece789e91bf77
Source noteuspto-grants-2004_04