HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylstannane → 4-Chloro-2-(tributylstannyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylstannane | HCID 5948 | — |
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Product | 4-Chloro-2-(tributylstannyl)pyrimidine | HCID 14976304 | 44.7% |
Reaction Steps
Using the procedure described in Example 1, Step 1, use LDA, tributyltin hydride (10.8 g, 37.2 mmol) and 2,4-dichloropyrimidine (5.2 g, 34.9 mmol)) to obtain the desired compound (6.3 g). 1H NMR (CDCl3) δ8.52 (d, 1H), 7.18 (d, 1H), 1.58 (m, 6H), 1.30 (q, 6H), 1.18 (t, 6H), 0.86 (t, 9H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727254B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-045a67f12c2a436faa283aa005c05c93 |
| Source note | uspto-grants-2004_04 |