HCID 22725102, compound → HCID 22725100, compound

Participants

Reaction Steps

Hydrogenate the product of Step 1 (22 mg) in CH3OH-EtOAc (1:1, 10 ml) and NH3/CH3OH (7N, 1 ml) in the presence of Lindlar catalyst at 1 atm for 2 h, filter and concentrate to produce the title compound. 1H NMR (CDCl3) δ9.15 (s, 1H), 8.70 (d, 1H), 8.00 (m, 2H), 7.80 (d, 1H), 7.25 (m, 4H), 7.19 (t, 2H), 5.61 (s, 1H), 3.15 (br s, 2H), 2.50 (dd, 2H), 2.25 (m, 4H), 1.65 (d, 2H).

Provenance & Evidence