Tetrabutylammonium Fluoride → HCID 22725104, compound

HRID 2086589Notes

Reaction equation

HRID 2086589 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[Cl:39])[N:9]1[CH:14]2[CH2:15][CH2:16][CH:10]1[CH2:11][C:12]([C:18]1[C:23]([CH2:24]O[Si](C(C)(C)C)(C)C)=[CH:22][CH:21]=[CH:20][N:19]=1)([OH:17])[CH2:13]2.[F-].C([N+:45](CCCC)(CCCC)CCCC)CCC>>[NH2:45][CH2:24][C:23]1[C:18]([C:12]2([OH:17])[CH2:11][CH:10]3[N:9]([CH:8]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=4[Cl:39])[C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[Cl:1])[CH:14]([CH2:15][CH2:16]3)[CH2:13]2)=[N:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 69542443HCID 69542443, compound

Product 1

HCID 22725104HCID 22725104, compound

Procedure

Follow the procedure of Step 4 of Example 15, using the product from Step 3 (12.3 g, 21.1 mmol) and tetrabutylamonium fluoride (11 g, 42.2 mmol) to give the desired compound.

Sources & evidence

ORD record
ord-2a707035b4cd4150ad2e2675a0a99bd1
Source dataset
uspto-grants-2004_04
Patent number
US06727254B2

Reaction notes

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