Pyridine → HCID 91490121, compound

Participants

Reaction Steps

Stir a solution of the product from Step 1 (64.5 mg, 0.128 mmol), N-Boc-ethylenediamine (123 mg, 0.77 mmol) and pyridine (12 mg, 0.154 mmol) at 110° C. in a sealed tube for 3.5 h. Cool to RT, add N-Boc-ethylenediamine (0.3 ml) and heat at 140° C. overnight. Cool to RT, quench the reaction with H2O, extract with EtOAc, dry and concentrate. Purify the residue by column chromatography to give the desired product.

Provenance & Evidence