HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Diethyl 2-({4-[(acetyloxy)methyl]-2-iodoanilino}methylene)malonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Diethyl 2-{[4-(hydroxymethyl)-2-iodoanilino]methylene}malonate | HCID 22724545 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Diethyl 2-({4-[(acetyloxy)methyl]-2-iodoanilino}methylene)malonate | HCID 22724556 | 87% |
Reaction Steps
A solution of diethyl 2-{[4-(hydroxymethyl)-2-iodoanilino]methylene}malonate (0.20 g) and acetic anhydride (0.054 mL) in acetic acid (0.24 mL) is heated at 80° C. overnight. The reaction is cooled to room temperature and poured into 50 mL of water. The resulting solid is filtered and dried to yield 0.19 g (87%) of diethyl 2-({4-[(acetyloxy)methyl]-2-iodoanilino}methylene)malonate as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727248B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-e403926e0f0f43ea8435d896334af639 |
| Source note | uspto-grants-2004_04 |