HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2086607Generated: October 29, 2026
4-Chlorobenzylamine → HCID 178522929, compound
https://huagongshe.com/reaction/2086607
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chlorobenzylamine | HCID 66036 | — |
| Reactant | HCID 178469656 | HCID 178469656 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 178522929 | HCID 178522929 | 73% |
Reaction Steps
A suspension of ethyl 6-[(acetyloxy)methyl]-4-hydroxy-8-iodo-3-quinolinecarboxylate (0.90 g) and 4-chlorobenzylamine (2.6 mL) is heated at 180° C. for 1 h. The reaction is cooled to room temperature and diluted with Et2O. The resulting solid is filtered and triturated with acetone to yield 0.74 g (73%) of N-(4-chlorobenzyl)-4-hydroxy-6-(hydroxymethyl)-8-iodo-3-quinolinecarboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06727248B2 |
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| Source dataset | uspto-grants-2004_04 |
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| ORD ID | ord-90546b7e020d4564ba0c99e818164ac3 |
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| Source note | uspto-grants-2004_04 |
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