Furan-3-boronic acid → HCID 22316747, compound

HRID 2086641Notes

Reaction equation

HRID 2086641 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=3)=[CH:11][CH:10]=[C:9]2[CH3:23])=[CH:4][C:3]=1[Cl:24].[O:25]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26]1>>[Cl:24][C:3]1[CH:4]=[C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=3)=[CH:11][CH:10]=[C:9]2[CH3:23])[CH:6]=[CH:7][C:2]=1[C:27]1[CH:28]=[CH:29][O:25][CH:26]=1

Participants

3

Reactant 2

HCID 2734358Furan-3-boronic acidHCID 22316675HCID 22316675, compound

Product 1

HCID 22316747HCID 22316747, compound

Procedure

The title compound was prepared according to the procedure of Example 35 using 1-(4-bromo-3-chlorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole instead of 1-(4-bromophenyl)-2-[3-fluoro-4-(methylsulfonyl)phenyl]-5-methyl-1H-pyrrole and 3-furanboronic acid instead of 2-furanboronic acid in step 4.

Sources & evidence

ORD record
ord-255495a4994a4ff880ad7f468db8b75a
Source dataset
uspto-grants-2004_04
Patent number
US06727238B2

Reaction notes

Loading…