Furan-2-boronic acid → HCID 86584957, compound

HRID 2086659Notes

Reaction equation

HRID 2086659 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1B(O)O.Br[C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]([C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)[N:19]=[C:18]([CH2:31][OH:32])[CH:17]=2)=[CH:12][CH:11]=1>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]([C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:28])=[O:29])=[CH:23][CH:22]=3)[N:19]=[C:18]([CH2:31][OH:32])[CH:17]=2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 2734357Furan-2-boronic acidHCID 86584958HCID 86584958, compound

Product 1

HCID 86584957HCID 86584957, compound

Procedure

The title compound was prepared according to the procedure of Example 1 using 2-furanboronic acid instead of 2-thiophenboronic acid acid and 4-[5-[4-Bromophenyl]-3-hydroxymethyl-[4-(methylsulfonyl)phenyl]-1H-pyrazole instead of 1-[4-(Methylsulfonyl)phenyl]-5-(4-bromophenyl)-3-trifluoromethyl-1H-pyrazole in step 2.

Sources & evidence

ORD record
ord-d16c673711d747989686c3589a861eb7
Source dataset
uspto-grants-2004_04
Patent number
US06727238B2

Reaction notes

Loading…