Furan-2-boronic acid → HCID 22316679, compound

HRID 2086660Notes

Reaction equation

[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1B(O)O.Br[C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]([C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)[N:19]=[C:18]([C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH:17]=2)=[CH:12][CH:11]=1.CS(C1C=CC(N2C(C3C=CC(Br)=CC=3)=CC(C(F)(F)F)=N2)=CC=1)(=O)=O>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]([C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)[N:19]=[C:18]([C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH:17]=2)=[CH:12][CH:11]=1

Participants

Reactant 3

HCID 2734357Furan-2-boronic acid

HCID 15340994HCID 15340994, compound

HCID 22316925HCID 22316925, compound

Product 1

HCID 22316679HCID 22316679, compound

Procedure

The title compound was prepared according to the procedure of Example 1 using 2-furanboronic acid instead of 2-thiophenboronic acid and Ethyl 5-(4-bromophenyl)-1-[4-(methylsulfonyl)phenyl]-1H-pyrazole-3-carboxylate prepared according to the procedure of EXAMPLE 63, step1) instead of 1-[4-(Methylsulfonyl)phenyl]-5-(4-bromophenyl)-3-trifluoromethyl-1H-pyrazole.

Workup

customprepared

Sources & evidence

ORD record: ord-cc758082cc9d4b1793400ec5185567eb
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06727238B2

Reaction notes

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