HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2086751Generated: October 28, 2026
Trifluoroacetic acid → 2-amino-3-(1H-indol-3-yl)-N-(2-methoxybenzyl)propanamide
https://huagongshe.com/reaction/2086751
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | 2-t-butoxycarbonylamino-3-(1H-indol-3-yl)-N-(2-methoxybenzyl)propanamide | HCID 10788407 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-amino-3-(1H-indol-3-yl)-N-(2-methoxybenzyl)propanamide | HCID 10805858 | — |
Reaction Steps
To a mixture of the 2-t-butoxycarbonylamino-3-(1H-indol-3-yl)-N-(2-methoxybenzyl)propanamide prepared supra (25.1 g, 59.2 mmoles) and anisole (12 ml, 110.4 mmoles) at 0° C. was added dropwise an aqueous solution of trifluoroacetic acid (118 ml, 1.53 moles) in 50 ml of water. This mixture was stirred for one hour at 0° C., followed by stirring for about 2.5 hours at ambient temperature. The mixture was then refrigerated for about 16 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06727255B1 |
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| Source dataset | uspto-grants-2004_04 |
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| ORD ID | ord-6bc8e69f0104435fa5395d7e0336f585 |
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| Source note | uspto-grants-2004_04 |
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