反应详情

A mixture of 2-chloro-3-nitropyridine (1.96 g) and 3′-amino-N-methylacetanilide (2.03 g) in toluene (20 ml) was refluxed for 7 hours. The mixture was poured into a mixture of ethyl acetate and aqueous sodium bicarbonate solution. The organic phase was separated, washed with brine, dried over magnesium sulfate and concentrated. The resultant solid was collected and washed with isopropyl ether to give 2-[3-(N-methylacetamido)phenylamino]-3-nitropyridine (872 mg).

1. temperaturewas refluxed for 7 hours
2. customThe organic phase was separated
3. washwashed with brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. customThe resultant solid was collected
7. washwashed with isopropyl ether