Ethanol → HCID 22724364, compound

HRID 2086850Notes

Reaction equation

HRID 2086850 reaction equation
[C:1]([CH2:4][CH2:5][C:6]1[C:11](=[O:12])[N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH3:30])=[O:21])[CH:14]=2)[C:9]2[N:31]=[CH:32][CH:33]=[CH:34][C:8]=2[N:7]=1)([OH:3])=[O:2].[CH2:35](O)[CH3:36]>>[CH2:35]([O:2][C:1]([CH2:4][CH2:5][C:6]1[C:11](=[O:12])[N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH3:30])=[O:21])[CH:14]=2)[C:9]2[N:31]=[CH:32][CH:33]=[CH:34][C:8]=2[N:7]=1)=[O:3])[CH3:36]

Participants

3

Reactant 2

HCID 702EthanolHCID 22724153HCID 22724153, compound

Product 1

HCID 22724364HCID 22724364, compound

Procedure

To a suspension of 2-(2-carboxyethyl)-3-oxo-4-[3-[3-(2-methoxyphenyl)ureido]phenyl]-3,4-dihydropyrido[2,3-b]pyrazine (0.15 g) in ethanol (9 ml) was added conc. sulfonic acid (0.9 ml) and the mixture was refluxed for 30 minutes. After cooling, the reaction mixture was neutralized and ethanol was evaporated. Crystalline materials formed were collected, washed with water and dried to give 2-(2-ethoxycarbonylethyl)-3-oxo-4-[3-[3-(2-methoxyphenyl)-ureido]phenyl]-3,4-dihydropyrido[2,3-b]pyrazine (0.12 g).

Workup

  1. temperaturethe mixture was refluxed for 30 minutes
  2. temperatureAfter cooling
  3. customethanol was evaporated
  4. customCrystalline materials formed
  5. customwere collected
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-0d1a5fc1268146179e98bdbd00e68b5c
Source dataset
uspto-grants-2004_04
Patent number
US06727245B2

Reaction notes

Loading…