HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dichlorobenzoyl chloride → 4-[3-(3,5-Dichlorobenzoylamino)phenyl]-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazinehydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dichlorobenzoyl chloride | HCID 76191 | — |
| Reactant | 4-(3-Aminophenyl)-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine | HCID 22724026 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-[3-(3,5-Dichlorobenzoylamino)phenyl]-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazinehydrochloride | HCID 22724186 | 130.8% |
Reaction Steps
To a solution of 4-(3-aminophenyl)-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (329 mg) in chloroform (5 ml) was added 3,5-dichlorobenzoylchloride (220 mg). The mixture was stirred at room temperature for 15 minutes and concentrated. The residue was crystallized from methanol to give 4-[3-(3,5-dichlorobenzoylamino)phenyl]-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine.hydrochloride (370 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727245B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-c3979eaee8384ec9908f34f9685c2cc9 |
| Source note | uspto-grants-2004_04 |