Benzoyl Peroxide → HCID 22724279, compound

HRID 2086878Notes

Reaction equation

HRID 2086878 reaction equation
[CH3:1][C:2]1[C:7](=[O:8])[N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N:15]3[C:19](=[O:20])[CH2:18][CH2:17][C:16]3=[O:21])[CH:10]=2)[C:5]2[N:22]=[CH:23][CH:24]=[CH:25][C:4]=2[N:3]=1.[Br:26]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>>[Br:26][CH2:1][C:2]1[C:7](=[O:8])[N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N:15]3[C:16](=[O:21])[CH2:17][CH2:18][C:19]3=[O:20])[CH:10]=2)[C:5]2[N:22]=[CH:23][CH:24]=[CH:25][C:4]=2[N:3]=1

Participants

4

Reactant 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 22724317HCID 22724317, compound

Product 1

HCID 22724279HCID 22724279, compoundYield 68.6%

Procedure

The solution of 2-methyl-4-(3-succinimidophenyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (18.4 g), N-bromosuccinimide (12.7 g) and benzoylperoxide (1.6 g) were refluxed for 4 hours. The mixture was evaporated and purified by chromatography (chloroform) to obtain 2-bromomethyl-4-(3-succinimidophenyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (15.6 g) as yellow crystals.

Workup

  1. customThe mixture was evaporated
  2. custompurified by chromatography (chloroform)

Sources & evidence

ORD record
ord-b28a5e4f3c7a4f38a2aeca56aaef158d
Source dataset
uspto-grants-2004_04
Patent number
US06727245B2

Reaction notes

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