Phthalic Anhydride → HCID 22724277, compound

HRID 2086879Notes

Reaction equation

HRID 2086879 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[C:10]([N:14]3[C:19](=[O:20])[C:18]([CH2:21][C:22]4[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=4)=[N:17][C:16]4[CH:28]=[CH:29][CH:30]=[N:31][C:15]3=4)[CH:11]=[CH:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.[C:32]1(=[O:42])[O:37][C:35](=[O:36])[C:34]2=[CH:38][CH:39]=[CH:40][CH:41]=[C:33]12>O1CCOCC1.O>[C:35]([C:34]1[CH:38]=[CH:39][CH:40]=[CH:41][C:33]=1[C:32]([NH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[C:10]([N:14]3[C:19](=[O:20])[C:18]([CH2:21][C:22]4[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=4)=[N:17][C:16]4[CH:28]=[CH:29][CH:30]=[N:31][C:15]3=4)[CH:11]=[CH:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1)=[O:42])([OH:37])=[O:36]

Participants

5

Reactant 2

HCID 6811Phthalic AnhydrideHCID 22724025HCID 22724025, compound

Product 1

HCID 22724277HCID 22724277, compoundYield 80.6%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-[3-(3-aminophenyl)phenyl]-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (100 mg) and phthalic anhydride (48 mg) in dioxane (3 ml) was stirred overnight at room temperature. The reaction mixture was diluted with water, and precipitated crystals were collected to give 4-[3-[3-(2-carboxybenzoylamino)phenyl]phenyl]-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (110 mg).

Workup

  1. customprecipitated crystals
  2. customwere collected

Sources & evidence

ORD record
ord-0945712b0df54adba1a5b27c372ec52f
Source dataset
uspto-grants-2004_04
Patent number
US06727245B2

Reaction notes

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