HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 9921248, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Cyclopentanone | HCID 8452 | — |
| Reactant | 1-(Thiophen-3-yl)ethanone | HCID 15116 | — |
| Reactant | 3-Oxo-3-(thiophen-3-yl)propanenitrile | HCID 2740075 | — |
| Reactant | Sulfur | HCID 5362487 | — |
| Product | HCID 9921248 | HCID 9921248 | 71% |
Reaction Steps
The procedure of Example 1 was followed except that 3-acetylthiophene (Aldrich) was used in place of acetophenone to prepare the corresponding 2-(thiophene-3-carbonyl)acetonitrile (Steps A and B). Cyclopentanone (Aldrich), 2-(thiophene-3-carbonyl)acetonitrile, morpholine, and sulfur were reacted according to the procedure of Step C, Example 1, to afford the desired compound. Yield: 71%; IR (KBr) cm−1: 3330, 3117, 2846, 1569, 1448, 1435, 1265, 855, 836, 757, 715; 1H NMR (CDCl3):δ2.24 (m, 4H), 2.71 (m, 2H), 6.83 (bs, 2H), 7.33 (m, 2H), 7.56 (m, 1H); yellow solid, mp: 125-127° C. (petroleum ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727258B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-90e01c4312cd48f3b503e7ec89c27de9 |
| Source note | uspto-grants-2004_04 |