Morpholine → HCID 10269507, compound

Participants

Reaction Steps

The procedure of Example 1 was followed except that 3-acetylthiophene (Aldrich) was used in place of acetophenone to prepare the corresponding 2-(thiophen-3-carbonyl)acetonitrile (Steps A and B). 4-Benzyl-cyclohexanone (Rosowsky et al., (1999) J. Med. Chem. 42: 1007-1017), 2-(thiophen-3-carbonyl)acetonitrile, morpholine, and sulfur were reacted according to the procedure of Step C, Example 1, to afford the desired compound. Yield: 65%; IR (KBr) cm−1: 3401, 2920, 1560, 1547, 1419, 1260, 700; 1H NMR (CDCl3):δ0.79 (m, 1H), 1.29 (m, 2H), 1.49 (m, 1H), 2.17 (m, 3H), 2.66 (m, 2H), 7.02 (bs, 2H), 7.28 (m, 8H); mp: 57-58° C. (petroleum ether).

Provenance & Evidence