2-(Methylsulfonyl)ethanamine → HCID 9808378, compound

HRID 2086993Notes

Reaction equation

HRID 2086993 reaction equation
[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([F:34])=[C:24]([C:27]5[O:31][C:30]([CH:32]=O)=[CH:29][CH:28]=5)[CH:25]=4)[N:20]=[CH:19][N:18]=3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:35][S:36]([CH2:39][CH2:40][NH2:41])(=[O:38])=[O:37]>>[C:1]1([S:7]([C:10]2[CH:11]=[CH:12][C:13]([NH:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([F:34])=[C:24]([C:27]5[O:31][C:30]([CH2:32][NH:41][CH2:40][CH2:39][S:36]([CH3:35])(=[O:38])=[O:37])=[CH:29][CH:28]=5)[CH:25]=4)[N:20]=[CH:19][N:18]=3)=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 43405612-(Methylsulfonyl)ethanamineHCID 21952209HCID 21952209, compound

Product 1

HCID 9808378HCID 9808378, compound

Procedure

Prepared according to Procedure D from 5-(4-(4-Phenylsulphonylphenylamino)-7-fluoroquinazolin-6-yl)-furan-2-carbaldehyde (0.6 equiv) and 2-methanesulphonyl-ethylamine (1 equiv). 1H NMR (400 MHz, DMSO-d6) δ: 10.38(s, 1H), 8.87(d, 1H), 8.62(s, 1H), 8.11(d, 2H), 7.95(m, 4H), 7.63(m, 4H), 6.94(m, 1H), 6.51(d, 1H), 3.84(s, 2H), 3.25(m, 2H), 2.98(s, 3H), 2.95(m, 2H). ESI-MS m/z 579(M−1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bef05c0df5b3475e9ee7dc67a7b1a4c2
Source dataset
uspto-grants-2004_04
Patent number
US06727256B1

Reaction notes

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