4-Chloroaniline → HCID 12093166, compound

Participants

Reaction Steps

To a stirring solution of p-chloraniline (320 mg, 2.5 mmol) in 2.5 mL of acetic acid at room temperature, are added cyclohexane carboxaldehyde (0.30 mL, 2.5 mmol) and ethyl 6-(4-hydroxyphenyl)-2,4-dioxohexanoate (618 mg, 2.5 mmol). The reaction mixture is stirred at room temperature. After 30 minutes a white precipitate is formed. The solvent is removed under reduced pressure and the crude material recrystallized from a mixture of ether/methanol. The final compound is collected after filtration as a white crystalline solid m.p. 259° C.

Provenance & Evidence