HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Methoxy-1-[5-(4-methoxyphenyl)4benzylpyrazol-3-yl]benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 1,3-Propanedione, 2-ethyl-1,3-bis(4-methoxyphenyl)- | HCID 135305 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Methoxy-1-[5-(4-methoxyphenyl)4benzylpyrazol-3-yl]benzene | HCID 22725609 | — |
Reaction Steps
A mixture of the 1,3-diketone obtained in step 1 (1.0 equiv.), hydrazine (3.0 equiv.), conc. HCl aq. (catalytic amount) and ethanol was heated to reflux overnight. Cooled to rt and removed solvent in vacuo. Water and ethyl acetate were added. The organic layer was separated, washed with dil. HCI, brine, dried, filtered and the solvent was concentrated in vacuo to give the product 4-methoxy-1-[5-(4-methoxyphenyl)-4-benzylpyrazol-3-yl]benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727273B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-18ec8cc0d6644fab9433584df70824e5 |
| Source note | uspto-grants-2004_04 |