5-acetyl-2,3-dihydro-1H-indol-2-one → 5-Ethyl-1,3-dihydro-2H-indol-2-one

Participants

Reaction Steps

The 5-acetyloxindole (54 g, 308 mmol), acetic acid (400 ml) and palladium on carbon (10%, 5 g) are combined and treated with hydrogen for 14 hours at 55 psi. The catalyst is removed by filtering through a bed of Celite, the filtrate is concentrated under reduced pressure and the residue is treated with ether to give 5-ethyloxindole.

Provenance & Evidence