HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-Pramipexole (dihydrochloride);R-(+)-Pramipexole (dihydrochloride);KNS-760704 (dihydrochloride)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine | HCID 4885 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-Pramipexole (dihydrochloride);R-(+)-Pramipexole (dihydrochloride);KNS-760704 (dihydrochloride) | HCID 11615735 | — |
Reaction Steps
4,2 g of (±)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole was dissolved in 15 mL of hot methanol and 1.65 mL of 36% hydrochloric acid was added. The obtained suspension was stirred, cooled and precipitated solid was filtered off. The cake was washed with cold methanol and air-dried to give 4.2 g of product with m.p. 273-282° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727367B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-47794402c36e46d48a85e147dce7bc35 |
| Source note | uspto-grants-2004_04 |