3,5-Difluorobenzaldehyde → HCID 20722977, compound

HRID 2087149Notes

Reaction equation

HRID 2087149 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([N:13]2[CH:17]([C:18]3[CH:23]=[CH:22][C:21](F)=[C:20]([F:25])[CH:19]=3)[CH2:16][O:15][C:14]2=[O:26])=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:27]C1C=C(C=C(F)C=1)C=O>>[F:27][C:22]1[CH:23]=[C:18]([C@H:17]2[CH2:16][O:15][C:14](=[O:26])[N:13]2[C:11]([O:10][C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)=[O:12])[CH:19]=[C:20]([F:25])[CH:21]=1

Participants

3

Reactant 2

HCID 5881603,5-DifluorobenzaldehydeHCID 220490874-(3,4-Difluorophenyl)-3-(4-nitrophenyloxy-carbonyl)-2-oxo-oxazolidine

Product 1

HCID 20722977HCID 20722977, compound

Procedure

Following the procedure for the synthesis of 4-(3,4-difluorophenyl)-2-oxo-oxazolidine-3-carboxylic acid-4-nitro-phenyl ester, 3,5-diflourobenzaldehyde yielded the desired product. 1H NMR (400 MHz, CDCl3) δ 8.26 (d, 2H, J=9.3 Hz), 7.33-6.81 (m, 5H), 5.41 (dd, 1H, J=4.1, 8.7 Hz), 4.81 (t, 1H, J=9.3 Hz), 4.33 (dd, 1H, J=4.1, 9.3 Hz); Anal. Calc. for C16H10F2N2O6+0.2EtOAc: C, 52.84; H, 3.06; N, 7.34. Found: C, 53.26; H, 2.83; N, 7.73.

Sources & evidence

ORD record
ord-6fb9d13b2f8846a4955e788187aeb1d2
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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