3,4,5-Trifluorobenzaldehyde → HCID 69890066, compound

HRID 2087150Notes

Reaction equation

HRID 2087150 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([N:13]2[CH:17]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[C:20]([F:25])[CH:19]=3)[CH2:16][O:15][C:14]2=[O:26])=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:27]C1C=C(C=C(F)C=1F)C=O>>[O:26]=[C:14]1[N:13]([C:11]([O:10][C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)=[O:12])[C@@H:17]([C:18]2[CH:23]=[C:22]([F:27])[C:21]([F:24])=[C:20]([F:25])[CH:19]=2)[CH2:16][O:15]1

Participants

3

Reactant 2

HCID 27769543,4,5-TrifluorobenzaldehydeHCID 220490874-(3,4-Difluorophenyl)-3-(4-nitrophenyloxy-carbonyl)-2-oxo-oxazolidine

Product 1

HCID 69890066HCID 69890066, compound

Procedure

Following the procedure for the synthesis of 4-(3,4-difluorophenyl)-2-oxo-oxazolidine-3-carboxylic acid-4-nitro-phenyl ester, 3,4,5-triflourobenzaldehyde yielded the desired product. 1H NMR (400 MHz, CDCl3) δ 8.27 (d, 2H, J=9.0 Hz), 7.31 (d, 2H, J=9.0 Hz), 7.11-7.02 (m, 2H), 5.37 (dd, 1H, J=4.1, 9.0 Hz), 4.81 (apparent t, 1H, J=9.0 Hz), 4.33 (dd, 1H, J=4.1, 9.0 Hz); Anal. Calc. for C16H9F3N2O6: C, 50.27; H, 2.37; N, 7.33. Found: C, 50.56; H, 2.50; N, 7.49.

Sources & evidence

ORD record
ord-5b923d06b3674b819e541533d6c0a961
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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