反应详情

Prepared as above, using 1-(5-chloropentyl)-1H-indole (22.2 mg, 0.100 mmol), 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide (24.6 mg, 0.100 mmol), K2CO3 (27.6 mg, 0.200 mmol), NaI (23.0 mg, 0.150 mmol) and DMF (1.00 mL), giving the desired product as a yellow oil (36 mg, 81%). 1H NMR (400 MHz, CDCl3) δ 8.08-6.52 (m, 11H), 4.19 (t, 2H, J=7.2 Hz), 3.26-3.10 (m, 2H), 2.71-2.55 (m, 2H), 2.55-2.42 (m, 2H), 2.35-2.12 (m, 2H), 2.12-1.80 (m, 6H), 1.80-1.57 (m, 2H), 1.51-1.34 (m, 2H), 1.31 (d, 6H, J=6.8 Hz); ESMS m/e: 432.2 (M+H)+.

1. customPrepared as above,