Butyryl chloride → N-[4-(4-piperidinyl)phenyl]butanamide

HRID 2087246Notes

Reaction equation

HRID 2087246 reaction equation
C[CH:2]([CH3:18])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:8][CH:7]=1)=[O:4].N[C:20]1C=CC(C2CCN(C(OC(C)(C)C)=O)CC2)=CC=1.C(Cl)(=O)CCC>>[NH:15]1[CH2:14][CH2:13][CH:12]([C:9]2[CH:8]=[CH:7][C:6]([NH:5][C:3](=[O:4])[CH2:2][CH2:18][CH3:20])=[CH:11][CH:10]=2)[CH2:17][CH2:16]1

Participants

4

Reactant 3

HCID 8855Butyryl chlorideHCID 21940085tert-Butyl 4-(4-aminophenyl)piperidine-1-carboxylateHCID 219572582-methyl-N-[4-(4-piperidinyl)phenyl]propanamide

Product 1

HCID 21957274N-[4-(4-piperidinyl)phenyl]butanamide

Procedure

Prepared by the procedure for 2-methyl-N-[4-(4-piperidinyl)phenyl]propanamide using tert-butyl 4-(4-aminophenyl)-1-piperidinecarboxylate and butanoyl chloride: ESMS m/e: 247.2 (M+H)+.

Sources & evidence

ORD record
ord-9608b40118bb4aa4aae91ab170a4fc9c
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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