3-Chloro-4'-methoxypropiophenone → N-(3-{1-[3-(4-Methoxyphenyl)-3-oxopropyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 2087264Notes

Reaction equation

HRID 2087264 reaction equation
Cl[CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1)=[O:5].[CH3:14][CH:15]([CH3:31])[C:16]([NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:20]=1)=[O:17]>>[CH3:13][O:12][C:9]1[CH:10]=[CH:11][C:6]([C:4](=[O:5])[CH2:3][CH2:2][N:28]2[CH2:29][CH2:30][CH:25]([C:21]3[CH:20]=[C:19]([NH:18][C:16](=[O:17])[CH:15]([CH3:14])[CH3:31])[CH:24]=[CH:23][CH:22]=3)[CH2:26][CH2:27]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 2332553-Chloro-4'-methoxypropiophenoneHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 22048734N-(3-{1-[3-(4-Methoxyphenyl)-3-oxopropyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Procedure K (KI) and Scheme E (K2cO3) using 3-chloro-1-(4-methoxyphenyl)-1-propanone and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 409.2 (M+H)+.

Sources & evidence

ORD record
ord-955c728ac71c49859b7b824cd991820e
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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