2-Chloro-4-methylphenol → N-(3-{1-[3-(4-Bromophenyl)-3-(2-chloro-4-methylphenoxy)propyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 2087290Notes

Reaction equation

HRID 2087290 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:29])[CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[CH:18]=[C:19]([NH:23][C:24](=[O:28])[CH:25]([CH3:27])[CH3:26])[CH:20]=[CH:21][CH:22]=3)[CH2:13][CH2:12]2)=[CH:4][CH:3]=1.[Cl:30][C:31]1[CH:36]=[C:35]([CH3:37])[CH:34]=[CH:33][C:32]=1O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([O:29][C:32]2[CH:33]=[CH:34][C:35]([CH3:37])=[CH:36][C:31]=2[Cl:30])[CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[CH:18]=[C:19]([NH:23][C:24](=[O:28])[CH:25]([CH3:26])[CH3:27])[CH:20]=[CH:21][CH:22]=3)[CH2:13][CH2:12]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 148512-Chloro-4-methylphenolHCID 22048618N-(3-{1-[3-(4-bromophenyl)-3-hydroxypropyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Product 1

HCID 22048994N-(3-{1-[3-(4-Bromophenyl)-3-(2-chloro-4-methylphenoxy)propyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Prepared by Procedure A and Scheme AN using N-(3-{1-[3-(4-bromophenyl)-3-hydroxypropyl]-4-piperidinyl}phenyl)-2-methylpropanamide and 2-chloro-4-methylphenol: ESMS m/e: 583.0 (M+H)+.

Sources & evidence

ORD record
ord-1890600a8a8141f48af322e8eb295c57
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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